2018 is likely to be overshadowed by the relationships between the U.S. on the one hand, a rising China and its strategic partnership with Russia on the other.
There is no fatality towards increased tension. It seems to be, however, more likely than a wise and cooperative approach, considering notably the overall transitional setting and the U.S. perspective and behaviour.
Most other issues will be impacted by the way these relationships develop.
Meanwhile, the increasing importance of Artificial Intelligence, its multiple uses and advances, could very well start very deeply transforming the world.